PHQ‑2: Patient Health Questionnaire‑2

The Patient Health Questionnaire‑2 (PHQ‑2) consists of the first two questions of the PHQ‑9 and asks about depressed mood and loss of interest or pleasure over the past two weeks. The PHQ‑2 serves as a quick “first‑step” screening tool for depression. If you answer “not at all” to both questions, no further action may be necessary. If you respond affirmatively to either item, the full PHQ‑9 or a clinical interview should follow.

Evidence & validation: Research demonstrates that a total score of 3 or greater on the PHQ‑2 is the optimal cut‑off for identifying major depressive disorder. In one study, a score of 3 had 82.9% sensitivity and 90% specificity for major depression. Although the PHQ‑2 has sensitivity comparable to the PHQ‑9, it has slightly lower specificity. A positive result is therefore a signal to complete the PHQ‑9 or arrange a clinical evaluation to determine diagnosis and severity.

Why use it? Depression is common yet under‑diagnosed. The PHQ‑2 offers a rapid, easy‑to‑administer screener that can be used in busy clinical settings, online assessments, or self‑checks. It is publicly available and free of charge, and is recommended by guidelines for adults and adolescents aged 12 and older. Because it takes less than a minute to complete, it is ideal for initial screening in primary care, behavioral health, obstetrics, and research settings.

Alternatives: A positive PHQ‑2 should be followed by the PHQ‑9, which provides a more comprehensive assessment and severity score. Other validated instruments include the Edinburgh Postnatal Depression Scale for perinatal screening, the Geriatric Depression Scale for older adults, and the Beck Depression Inventory. These tools may be more appropriate in certain populations.

Important disclaimer: The PHQ‑2 is a screening tool and cannot diagnose depression. A positive screen should always be followed by further assessment. If you have thoughts of self‑harm or suicide, seek professional help immediately. In the U.S., call the 988 Suicide & Crisis Lifeline.

Reference: View the PHQ‑2 scoring guidelines from the University of Washington’s National HIV Curriculum and the PHQ‑2/PHQ‑9 instructions from the instrument developers.

You'll answer two questions about how often you've been bothered by (1) little interest or pleasure in doing things and (2) feeling down, depressed or hopeless over the past two weeks. Each response is scored from 0 (Not at all) to 3 (Nearly every day). The total score ranges from 0 to 6. Completing the PHQ‑2 typically takes less than a minute.